| | Maternal/family history of cardiac disease
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| | A known or newly diagnosed history of hypertension (high blood pressure)
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| | Preeclampsia (toxemia)
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| | Maternal metabolic diseases, including diabetes (both pregestational and gestational types)
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| | Infectious diseases (to include parvovirus, toxoplasmosis, hepatitis, HIV and AIDS) |
| | Maternal/family history of renal, gastrointestinal disease and cystic fibrosis |
| | An abnormal AFP (Alpha fetoprotein) blood test (including the suspicion of a neural tube defect) |
| | An abnormal triple screen (including the suspicion of a chromosomal abnormality such as Trisomy 21 [Down Syndrome]. Trisomy 13 or Trisomy 18) |
| | Multiple gestation (twins and higher order multiples) |
| | Poor past obstetrical history (to include past preterm deliveries, preterm labor, preterm cervical dilation, premature rupture of membranes, repetitive pregnancy loss) |
| | Suspected abnormal fetal growth—both macrosomia (a baby that is too large) or fetal growth restriction (a baby that is too small) |
| | Maternal lupus |
| | Red cell alloimmunization (Rh-mother sensitized to an Rh+ fetus) |
| | A known/suspected fetal anomaly |
| | The need for genetic counseling |
| | The need for anepartum fetal testing |
| | The need for invasive fetal testing/procedures such as:
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